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Ranitidine base
Details of ranitidine base
CAS:6131-90-4
Chemical Name: N-[2-[[5-[(Dimethylamino)methyl]-2-furanylmethyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Anhydrous)
Classification: Organic base
Molecule: C13H22N4O3S
Molecule Weight: 314.41
Structural Formula:
Quality Standard: Q/82HL03-2004
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Parameter of ranitidine base
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| Characteristics | White or almost white powder |
| Assay (HPLC) | 97.5%~102.0% |
| Any impurity | not more than 0.2% |
| Moisture (K.F method) | not more than 0.5% |
| Package | 25kg/bag |
| Application | Intermediate of Ranitidine |
Methods of Manufacturing
5-[(Dimethylamino)methyl]-2-furanmethanol (I) reacts with cysteine to form 2-[[5-[(dimethylamino)methyl-2-furyl]methyl] Thio]ethylamine (II). 230g of N-methyl-1-methylthio-2-nitroethylene methylamine was dissolved in 400ml of water, heated and stirred at 45-50°C, 321g of compound (II) was added dropwise within 4h, and stirring was continued for 3.5h after the addition. Then reflux for another 0.5h and cool to. At 70°C, add 2L of 4-methyl-2-pentanone. The water was azeotropically distilled under reduced pressure (34.7kPa), and then reacted with 10g activated carbon at 50°C. After removing the activated carbon by filtration, cool to 10°C, filter the precipitated ranitidine, and dry it to obtain about 380g, with a melting point of 69-70°C.
Uses of ranitidine base
Long-acting and potent H2 receptor antagonist can effectively inhibit gastric acid secretion caused by histamine, pentagastrin and food stimulation, reduce the basic regular gastric acid and inhibit the activity of gastric enzymes. Its intensity of action is 5-8 times that of cimetidine. This product is suitable for benign gastric and duodenal ulcers, postoperative ulcers, reflux esophagitis and Zhuo-Ehrlid~"s syndrome.
Synonyms
- Ranitidine HCL
- Ranitidine hydrochloride
- Rantidine HCL
- Ranitidin AL
- Ranitidin AWD
- Ranitidin Arcana
- Ranitidin Atid
- Ranitidin Basics
- Ranitidin Duncan
- Ranitidin Dyna
- Ranitidin Helvepharm
- Ranitidin Heumann
- Ranitidin Hexal
- Ranitidin Merck
- Ranitidin Millet
- Ranitidin NM
- Ranitidin Normon
- Ranitidin PB
- Ranitidin Stada
- Ranitidin von ct
- Ranitidin-Cophar
- Ranitidin-Isis
- Ranitidin-ratiopharm
- Ranitidina Tamarang
- Ranitidina predilu Grif
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Hebei Haili fragrances Co., Ltd. was established in December 2003, covering an area of 26700m2, with a registered capital of 40.2 million, 281 employees and a sales volume of 198 million in 2019.
The company specializes in the development, production and sales of chemical APIs, spices, polyimide monomers.
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